This work group report first summarizes the most important stakeholder use cases for exploring breakthrough innovations through the application of Web 3.0 technologies. Next, t he report summarizes major technology challenges and issues that cross-cut these use cases. The report then highlights possible performance metrics that could be used in evaluating the impacts of pilot projects addressing these use cases as well as ethical considerations. The report concludes by providing a proposed template for Work Groups 2, 3, and 4 to use in developing pilot project ideas for these stakeholder use cases, technical challenges and issues, performance metrics, policy barriers, and ethical considerations.